今年5月刊 《新发现SCIENCE&VIE>(据说是欧洲科学人文第一杂志）发文：有可能是微生物导致了大脑疾病（包括痴呆和PD等），如疱疹病毒影响痴呆AD（如Antiviral Drugs May Slow Alzheimer’s Progression ScienceDaily (Oct. 17, 2011) — Antiviral drugs used to target the herpes virus could be effective at slowing the progression of Alzheimer’s disease (AD), a new study shows.）,肠道感染影响PD(包括幽门螺旋杆菌、难辨状芽孢杆菌），据说对难辨状芽孢杆菌的治疗8个有7个有效。有关专家是HEIKO BRAAK ,THOMAS BORADY.认为阿昔洛韦可抑制AD，抗生素可抑制PD.有兴趣的可看以下，也可以讨论啊。幽门螺旋杆菌的影响好像有公论了。
Parkinson’s Disease: A Multifactorial Hypothesis
Heidi Lindborg, MLIS
March 3, 2009
Several years ago a male in his late forties was evaluated in a state psychiatric hospital.
He had a normal development and childhood, was a college graduate and an accountant for a National Guard Unit. He had no previous psychiatric history. One day he developed
severe burning sensations of the face and head and confusion, and was admitted to a
general hospital, where he stayed for several days. He received symptomatic treatment and was discharged with a diagnosis of "fever of unknown origin, improved." At home, he was said to be confused, "not himself," and he mostly sat in his chair, seemed to be in poor contact with his surroundings, responded only to simple commands, and importantly, could no longer calculate.
Later, he was taken to a local mental health unit center, where he was diagnosed for
unclear reasons as a "paranoid schizophrenic" and was treated with a variety of
neuroleptics without success. Over the years, he had several state psychiatric hospitalizations, with similar diagnosis, similar treatment and similar outcome. Approximately three years after the onset of his illness, he suffered a relapse, with high fever, "of unknown cause," and received similar symptomatic treatment. His condition then progressed to a bed and chair existence. Eventually, his medications were restricted to benzodiazapines because of "severe extrapyramidal side-effects," with even the smallest doses of neuroleptics.
When seen, eight years after the onset of the illness, he was sitting in a wheelchair, with
extreme fatigue, depression, malaise, resting tremor, bradykinesia, and micrographia, most of which were attributed to neuroleptics (which he had not been given for several years).
Because of this history, presentation, odd diagnosis, and extensive record of unsuccessful
treatment, a literature search was done, after which a presumptive diagnosis of chronic
relapsing Herpes Simplex Type 1 encephalitis was made, with subsequent confirmation by elevated IgG antibody titers. When treated with 1,000 mgm. of acyclovir per day for ten days, and 200 mgm. of amatadine per day, he was astonishingly restored to his premorbid state within a three-week period, including his substantial mathematical abilities. He was then successfully presented to the chairman of a local university department of psychiatry at grand rounds as a case of chronic Herpes Simplex Type 1 encephalitis, improved. At the time of his discharge, he was well oriented, had good focus of attention, good abstracting ability, a pleasant sense of humor, and importantly, no Parkinsonian symptoms.