唑尼沙胺可以抑制左旋多巴上调的免疫和炎症反应问题
临床应用Zonisamide(唑尼沙胺)治疗帕金森症的最新机制解释(续)
左旋多巴是PD的有效药物,但控制症状的效果会渐差,到底是药的问题,还是疾病的发展,还是什么原因,以下报告可能是其中一个原因。
事实上,左旋多巴在应用的时候,会有一个上调免疫和炎症的问题,免疫炎症会造成胶质细胞的活化,引起多巴胺细胞的衰亡,所以如何在应用左旋多巴的时候(除了用雷沙吉兰这只独立的神经保护剂以外),减低免疫和炎症活动,即可以降低疾病进展的速度。
最近日本宫崎大学和滨松医科大学的学者从基因技术层面上肯定了唑尼沙胺在联合左旋多巴治疗帕金森症中提供的保护机制,促进神经系统的功能和发展,这是在国际生物学杂志BBRC上的报告,由于有版权(41.95美元),我只能在此出一个提要,有兴趣了解多一点的可以自己去付款下载。
Effect of zonisamide co-administration with levodopa on global gene expression in the striata of rats with Parkinson’s disease
Yuto Uedaa, Shoko Tokashikia, Ai Kanemarua, Toshio Kojimab, ,
a Section of Psychiatry, Department of Clinical Neuroscience, Faculty of Medicine, University of Miyazaki, Miyazaki 889-1692, Japan
b Research Equipment Center, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan
Corresponding author. Address: Research Equipment Center, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashiku, Hamamatsu 431-3192, Japan. Fax: +81 53 435 2300.
Received 4 October 2012Available online 25 October 2012
Abstract
The anti-epileptic drug zonisamide is reported to exert beneficial effects in patients with Parkinson’s disease. To elucidate the pathophysiological mechanisms underlying the anti-parkinsonism effects of zonisamide, we examined the effect of zonisamide co-administered with levodopa in the striata of rats with 6-hydoroxydopamine hemiparkinsonism by using a DNA microarray for genome-wide gene expression profiling. We found that the expression of some genes related to metabolism and nervous system development and function were upregulated by zonisamide; expression of these genes was downregulated by levodopa. Furthermore, many genes related to the immune system and inflammation were downregulated by zonisamide, and their expression was upregulated by levodopa. These results indicate that zonisamide has a protective effect when co-administered with levodopa.
Highlights
► Long-term use of levodopa has been reported to have adverse effects. ► Zonisamide (ZNS) has beneficial effects for patients with Parkinson’s disease (PD). ► We aimed to elucidate the mechanism underlying ZNS’s protective effects against PD. ► Our results indicated neuroprotective effects of ZNS co-administered with levodopa.