回复137楼 undefi
回复137楼 undefi:回复135楼 章华
可以试试,日本人的体质和我们差不多,以下的报告讲唑尼沙胺的对病情的改善方面可以体现在颈部的僵硬,步态和手指僵硬,都是以改善肌张力过高的问题。
但用法肯定是从每天25mg开始,如果用于异动症的,短期需要达到75mg-100mg。
你服用中有什么问题再来交流,留意副作用。
Randomized, double-blind study of zonisamide with placebo in advanced Parkinson’s disease
M Muratta, K Hasegawa, I Kanazawa, Japan Zonisamide Study Group
P555, S198
One hundred thirty-six patients were randomized to receive zonisamide (at 50, 100, or 200 mg per day) or placebo as adjunctive therapy for 8 weeks. Low-dose zonisamide significantly improved UPDRS motor score vs placebo, while improvement from the other two doses just failed to reach significance. The authors report that zonisamide improved axial symptoms (neck rigidity, gait disturbance, postural instability) as well as limb rigidity.